Consideration of health equity is fundamental to enhancing the health of those who are economically/socially disadvantaged. A vital characteristic of health equity and therefore health disparity is the level of spatial access to health services and its distribution among populations. Adequate knowledge of health disparity is critical to enhancing the optimal allocation of resources, identification of underserved populations, and improving the efficiency and performance of the health system. The provision of such insight for sub-Saharan African (SSA) cities is a challenge and is severely limited in the literature. Accordingly, this study examined the disparities in potential spatial access to health services for four selected urban areas in Ghana based on: (a) the number of physicians per population; (b) access score based on a weighted sum of access components; (c) travel time to health services; and (d) the combined evaluation of linkages between travel distance, settlement area, population, and economic status. The overall spatial access to health services is low across all selected cities varying between 3.02 and 1.78 physicians per 10,000 persons, whereas the access score is between 1.70 and 2.54. The current number of physicians needs to be increased by about 5 times to satisfy the World Health Organization’s standard. The low spatial access is not equitable across and within the selected cities, where the economically disadvantaged populations were found to endure longer travel distances to access health services. Inequities were found to be embedded within the selected cities where economically poor populations are also disadvantaged in their physical access to healthcare. The health facilities in all cities have reasonable travel distances separating them but are inadequately resourced with physicians. Thus, increasing the physician numbers and related resources at spatially-targeted existing facilities would considerably enhance spatial access to health services.