Can behavioral interventions designed to treat childhood obesity be delivered in pediatric primary care settings? In this issue of JAMA, Epstein and colleagues report the results of the PLAN randomized trial, which tested a family-based behavioral intervention for the treatment of childhood obesity among those aged 6 to 12 years. The trial was implemented with rigorous clinical trial methods, overcoming obstacles during the peak of the COVID-19 pandemic, and had adequate retention to evaluate the study’s effectiveness over time. The results are also timely because the American Academy of Pediatrics recently released a clinical practice guideline that calls for renewed emphasis on intensive behavioral interventions for childhood obesity. There have been hundreds of clinical trials for pediatric weight management programs, and many have been effective. What makes this program different and does this trial provide evidence to support implementation in primary care?