• Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar

information for practice

news, new scholarship & more from around the world


advanced search
  • gary.holden@nyu.edu
  • @ Info4Practice
  • Archive
  • About
  • Help
  • Browse Key Journals
  • RSS Feeds

Effect of Nationwide Concurrent Drug Utilization Review Program on Drug-Drug Interactions and Related Health Outcome

ABSTRACT
Background

A computerized drug utilization review (DUR) program has provided physicians and pharmacists with alerts on drug-drug interactions, drug-age precautions, and therapeutic duplication in Korea since 2010. The purpose of this study was to evaluate the impact of the DUR program on health outcomes associated with drug-drug interactions (DDIs).

Methods

A uncontrolled before-after study was performed to investigate the impact of the nationwide DUR program on DDIs and related health outcomes. The study population consisted of people who used two types of DDI pairs before DUR implementation (January 2009 to December 2010) and post-DUR implementation (January 2012 to December 2013); 1) benzodiazepines with concurrent use of metabolic enzyme inhibitors, 2) QTc prolongation agents. The main outcome measures were all-cause and cause-specific hospitalization admissions or emergency department (ED) visits.

Results

This study included 107,874 people who used benzodiazepines with enzyme inhibitors and 8,489 who received co-medication of QTc prolongation agents. For patients receiving a combination of benzodiazepines and enzyme inhibitors, both all-cause hospitalization and cause-specific hospitalization decreased after DUR implementation, from 43.2% to 41.7% and 4.6% to 4.5% (adjusted odds ratio [OR]=0.96; 95% confidence interval (CI), 0.93-0.98; OR=0.89, 95% CI=0.84-0.99, respectively). For patients receiving co-medication of QTc prolongation agents, all-cause hospitalization (54.2%) was lower than before (54.9%) (OR=0.87, 95% CI=0.79-0.96), but no significant change was found for cause-specific hospitalization and ED visits.

Conclusion

Implementation of a DUR program may reduce the adverse health outcomes posed by DDIs in patients on combination of benzodiazepines and enzyme inhibitors potentially QTc-prolongation agents.

Read the full article ›

Posted in: Journal Article Abstracts on 08/17/2021 | Link to this post on IFP |
Share

Primary Sidebar

Categories

Category RSS Feeds

  • Calls & Consultations
  • Clinical Trials
  • Funding
  • Grey Literature
  • Guidelines Plus
  • History
  • Infographics
  • Journal Article Abstracts
  • Meta-analyses - Systematic Reviews
  • Monographs & Edited Collections
  • News
  • Open Access Journal Articles
  • Podcasts
  • Video

© 1993-2023 Dr. Gary Holden. All rights reserved.

gary.holden@nyu.edu
@Info4Practice