The goals of this paper are to review theoretical and empirical research on motivation and healthy aging at work and to outline directions for future research and practical applications in this area. To achieve these goals, we first consider the World Health Organization’s (WHO) definition of healthy aging in the context of paid employment and lifespan development in the work domain. Second, we describe contemporary theoretical models and cumulative empirical findings on age, motivation, and health and well-being at work, and we critically discuss to what extent they are consistent with the WHO definition of healthy aging. Finally, we propose several directions for future research in the work context that are aligned with the WHO definition of healthy aging, and we describe a number of interventions related to the design of work environments and individual strategies to promote the motivation for healthy aging at work.