More than 67 million people in the US (22%) speak a language other than English at home, and 25.6 million Americans (8%) have limited English proficiency (LEP), which is defined as a self-rated ability to speak English less than very well. Language barriers have been shown to impact multiple aspects of health care, including access to health care, health status, use of health services, patient-clinician communication, satisfaction with care, quality of care, patient safety, and clinical research. Nevertheless, far too often, language barriers have been left out of the conversation on patient safety. For example, although the landmark National Academy of Sciences book, To Err is Human: Building a Safer Health System, arguably spurred a revolution in patient safety, there is not a single mention of language barriers, interpreters, or translators in the book.