Using Louis’ formula, it is possible to obtain the observed information matrix and the corresponding large‐sample standard error estimates after the expectation–maximization (EM) algorithm has converged. However, Louis’ formula is commonly de‐emphasized due to its relatively complex integration representation, particularly when studying latent variable models. This paper provides a holistic overview that demonstrates how Louis’ formula can be applied efficiently to item response theory (IRT) models and other popular latent variable models, such as cognitive diagnostic models (CDMs). After presenting the algebraic components required for Louis’ formula, two real data analyses, with accompanying numerical illustrations, are presented. Next, a Monte Carlo simulation is presented to compare the computational efficiency of Louis’ formula with previously existing methods. Results from these presentations suggest that Louis’ formula should be adopted as a standard method when computing the observed information matrix for IRT models and CDMs fitted with the EM algorithm due to its computational efficiency and flexibility.