One in four deaths in the US is caused by cardiovascular disease (CVD), and early detection may be a key aspect of prevention. We assessed the probability of a first hard atherosclerotic cardiovascular disease (ASCVD) event within 10 years in US Non-Hispanic White and African American population aged 40–79 years. With data from 16 years of the National Health and Nutrition Examination Survey (NHANES), we utilized the 2013 Pooled Cohort Equations developed by the American College of Cardiology and the American Heart Association to calculate risk scores for a representative sample. NHANES is a repeated, cross-sectional survey aimed at assessing the health and nutritional status of the country. Out of 17,087 eligible participants, a sample of 1876 (11%) remained for the analysis after excluding participants missing data required to compute the scores. Our results showed that 25.2% of the sample had a greater than 10% risk of contracting ASCVD within 10 years, and we also found sex-, race-, and age-based disparities. The ASCVD risk scores can thus be used to evaluate the general cardiac health of the population. Results showed that a quarter of the US adult population was at risk to contract ASCVD in the next 10 years, indicating the need for targeted preventative measures. With the aging population and rise in obesity rates, these results may also indicate trend continuation of high CVD-related morbidity and mortality.