Psychotic experiences (PEs) that resemble the positive symptoms of psychotic disorders, yet fall below diagnostic thresholds in terms of severity, persistence, impairment, and distress, have increasingly been recognized as clinically meaningful phenomena. This is primarily based on the research from high-income countries (HICs), and the limited existent research on PEs in low- and middle-income countries (LMICs), home to 80% of the world’s population, has rarely directly compared LMICs to HICs. In this issue, Wüsten et al1 used a network analysis approach to find that adults in 5 LMICs were more likely to report PEs compared to those living in 8 HICs, but that PEs were also less distressing and less interconnected in LMICs, suggesting that PEs are of less clinical relevance in LMICs compared with HICs. We also find in this issue that the prevalence of schizophrenia is relatively uniform across countries regardless of income, and the related health burden appears to be particularly increasing in middle-income countries.2 As such, we must consider whether PEs that are phenomenologically similar may carry varying degrees of clinical significance across cultures and, if so, why this may vary by income.