Reynolds and colleagues (2018) highlight the role that comorbid medical conditions play in exacerbating negative quality of life outcomes for pediatric populations. They demonstrated that in minority youth with persistent asthma, those with more comorbid conditions also experienced, on average, poorer sleep and academic outcomes. More specifically, higher cumulative risk index (CRI) scores (i.e., more comorbidities) were significantly related to decreased sleep duration and increased school absences. CRI scores were also assessed as a moderator between asthma-related lung function and sleep and academic functioning. They found that better lung function was associated with better sleep efficiency for individuals with one comorbid condition; CRI scores did not moderate the relationships among the remaining models. Multiple comorbidities may create a more complex picture for understanding the relationship between lung function and sleep quality. Additionally, higher sleep-disordered breathing (SDB) risk was associated with more school absences in the full sample and in the Latino group, but not for the African-American group. However, African-American children had higher rates of SDB risk than Latino children. This work contributes to the literature on sleep problems in youth and underscores the compounding impact of chronic medical conditions on functional outcomes. However, certain family- and cultural-level components were not fully explored, and further research is needed to better understand the complex relationships between comorbidities of chronic health conditions and sleep quality.