A neuroscience-informed approach to music therapy may not appear to have many similarities to a humanistic one. However, a closer look at both reveals some commonalities, as well as some divergences, particularly in the conceptualization of common aspects to music therapy practice. Thus, the purpose of this article is to explore such similarities and differences and examine how ideas inherent in humanistic-leaning music therapy practice may inform and strengthen neuroscience-informed music therapy practice. After describing characteristics of the neuroscience-informed music therapy approach, we review current publications from this area of practice to see where humanistic principles are suggested. We then outline where standards of selfhood, agency, relationality, and aestheticality in particular can be infused in the clinical practice and research of the neuroscience-informed music therapist as a way to enhance client outcomes by allowing them input in realizing their own health and wellness.