Negative symptoms of schizophrenia account for much of the poor functional outcome in schizophrenia and are a significant unmet treatment need in a large proportion of patients.1,2 Reduction in negative symptoms could result in improved engagement in vocational, independent living, social and recreational activities. There is no doubt that effective treatment of negative symptoms in schizophrenia would have a profound effect on quality of life in people with schizophrenia and their families, as well as the mental health system and broader economy. Several expert recommendations, such as the NIMH-MATRICS Consensus Statement on Negative Symptoms,2 call for treatments for negative symptoms.