HIV is highly stigmatized throughout sub-Saharan Africa [1],[2]. In studies conducted among general population samples, stigma has been shown to impede uptake of HIV testing and increase sexual risk-taking behavior [3],[4]. Among HIV-infected persons, stigma has also been associated with inhibited serostatus disclosure to sexual partners and potential treatment supporters, delays in HIV antiretroviral therapy (ART) initiation, and ART non-adherence [5],[6],[7]. The stigma of HIV also intensifies the poverty, stress, and insecurity endemic to many resource-limited settings [8], resulting in worsened mental health [9], itself an important determinant of AIDS-related mortality [10]. Until we can better understand how to effectively intervene to reduce the stigma of HIV, it will continue to adversely affect the well-being of HIV-infected persons and undermine both treatment and prevention efforts throughout sub-Saharan Africa.