Abstract
To determine if, among overweight or obese women with gestational diabetes (GDM), weight loss after GDM diagnosis is associated
with lower infant birth weight within levels of overweight or obesity class. Overweight and obese women with singleton pregnancies
managed for GDM at a large diabetes and pregnancy program located in Charlotte, NC between November 2000 and April 2010, were
eligible for this retrospective cohort study. All were managed using a rigorous standardized clinical protocol. Clinical information
including maternal pre-pregnancy body mass index, gestational weight gain, treatment, and medical and obstetric history was
abstracted from medical records. The association of weight loss after GDM diagnosis and birth weight was analyzed using linear
regression stratified by maternal pre-pregnancy overweight or obesity class (I, II/III). Of the 322 women in this study 19 %
lost weight between diagnosis of GDM and delivery. After adjustment for maternal age, parity, race/ethnicity, gestational
week at first hemoglobin A1c (A1C), A1C at diagnosis, weight gain prior to GDM, treatment with insulin or oral hypoglycemic
agents, gestational age at delivery, and infant sex, weight loss was associated with 238.3 g lower mean infant birth weight
among overweight women (95 % CI −393.72, −82.95 g), but was not associated with lower mean infant birth weight among obese
class II/III women (95 % CI −275.61, 315.38 g). Weight loss, after diagnosis of GDM, is associated with lower infant birth
weight among overweight women, but not among obese class II/III women.
with lower infant birth weight within levels of overweight or obesity class. Overweight and obese women with singleton pregnancies
managed for GDM at a large diabetes and pregnancy program located in Charlotte, NC between November 2000 and April 2010, were
eligible for this retrospective cohort study. All were managed using a rigorous standardized clinical protocol. Clinical information
including maternal pre-pregnancy body mass index, gestational weight gain, treatment, and medical and obstetric history was
abstracted from medical records. The association of weight loss after GDM diagnosis and birth weight was analyzed using linear
regression stratified by maternal pre-pregnancy overweight or obesity class (I, II/III). Of the 322 women in this study 19 %
lost weight between diagnosis of GDM and delivery. After adjustment for maternal age, parity, race/ethnicity, gestational
week at first hemoglobin A1c (A1C), A1C at diagnosis, weight gain prior to GDM, treatment with insulin or oral hypoglycemic
agents, gestational age at delivery, and infant sex, weight loss was associated with 238.3 g lower mean infant birth weight
among overweight women (95 % CI −393.72, −82.95 g), but was not associated with lower mean infant birth weight among obese
class II/III women (95 % CI −275.61, 315.38 g). Weight loss, after diagnosis of GDM, is associated with lower infant birth
weight among overweight women, but not among obese class II/III women.
- Content Type Journal Article
- Pages 1-10
- DOI 10.1007/s10995-012-1044-5
- Authors
- Jodie Katon, Department of Epidemiology, University of Washington School of Public Health, P.O. Box 357236, Seattle, WA 98195, USA
- Gayle Reiber, Department of Epidemiology, University of Washington School of Public Health, P.O. Box 357236, Seattle, WA 98195, USA
- Michelle A. Williams, Department of Epidemiology, University of Washington School of Public Health, P.O. Box 357236, Seattle, WA 98195, USA
- David Yanez, Department of Biostatistics, University of Washington School of Public Health, Seattle, WA, USA
- Edith Miller, Carolinas Medical Center Diabetes and Pregnancy Program, Carolinas Medical Center, Charlotte, NC, USA
- Journal Maternal and Child Health Journal
- Online ISSN 1573-6628
- Print ISSN 1092-7875