Abstract
Purpose
The Fatigue Associated with Depression Questionnaire (FAsD) was developed to assess fatigue and its impact among patients
with depression. The purpose of this study was to examine the questionnaire’s responsiveness to change and identify a responder
definition for interpretation of treatment-related changes.
with depression. The purpose of this study was to examine the questionnaire’s responsiveness to change and identify a responder
definition for interpretation of treatment-related changes.
Results
Of the 96 participants, 55.2% were women, with a mean age of 43.4 years. The total score and both subscales demonstrated statistically
significant change with moderate to large effect sizes (absolute values ≥0.76). FAsD change scores were significantly correlated
with change on the Brief Fatigue Inventory (r ≥ 0.73; p < 0.001). FAsD mean change scores discriminated among patient subgroups differing by degree of improvement in patient- and
clinician-reported fatigue and depression. Responder definition for the two subscales and total score (0.67, 0.57, 0.62) was
estimated primarily based on mean change among patients who reported a small but important improvement in fatigue.
significant change with moderate to large effect sizes (absolute values ≥0.76). FAsD change scores were significantly correlated
with change on the Brief Fatigue Inventory (r ≥ 0.73; p < 0.001). FAsD mean change scores discriminated among patient subgroups differing by degree of improvement in patient- and
clinician-reported fatigue and depression. Responder definition for the two subscales and total score (0.67, 0.57, 0.62) was
estimated primarily based on mean change among patients who reported a small but important improvement in fatigue.
- Content Type Journal Article
- Pages 1-10
- DOI 10.1007/s11136-012-0142-6
- Authors
- Louis S. Matza, Outcomes Research, United BioSource Corporation, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA
- Kathleen W. Wyrwich, Outcomes Research, United BioSource Corporation, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA
- Glenn A. Phillips, Eli Lilly and Company, Indianapolis, IN, USA
- Lindsey T. Murray, Outcomes Research, United BioSource Corporation, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA
- Karen G. Malley, Malley Research Programming, Inc., Rockville, MD, USA
- Dennis A. Revicki, Outcomes Research, United BioSource Corporation, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA
- Journal Quality of Life Research
- Online ISSN 1573-2649
- Print ISSN 0962-9343