Abstract
Method
Grandchildren (N = 28,089, 49% female, aged 13–47 years in 2002) of a cohort born in Uppsala, Sweden, in 1915–1929 were studied in national
registers. We obtained data on final grade point average (GPA) in compulsory school, hospitalizations for unipolar depression,
grandparental/parental education and other parental social characteristics. Hospitalization in adolescence and adulthood were
studied separately, as were hospitalization for depression with or without a lifetime externalizing disorder.
registers. We obtained data on final grade point average (GPA) in compulsory school, hospitalizations for unipolar depression,
grandparental/parental education and other parental social characteristics. Hospitalization in adolescence and adulthood were
studied separately, as were hospitalization for depression with or without a lifetime externalizing disorder.
Results
Low compulsory school GPA (1–2 SD or >2 SD below average vs. average GPA) was associated with increased rate of adolescent
hospitalization for unipolar depression, both with externalizing comorbidity [hazard ratio (HR) point estimates of 66–80]
and without (HR point estimates of 4–6). By contrast, low GPA was only associated with first-time hospitalization in adulthood
for the subgroup with externalizing comorbidity (HR point estimates of 4–6). These associations were largely independent of
family education and social characteristics. Overall, low parental/grandparental education was not related to increased rates
of hospitalization.
hospitalization for unipolar depression, both with externalizing comorbidity [hazard ratio (HR) point estimates of 66–80]
and without (HR point estimates of 4–6). By contrast, low GPA was only associated with first-time hospitalization in adulthood
for the subgroup with externalizing comorbidity (HR point estimates of 4–6). These associations were largely independent of
family education and social characteristics. Overall, low parental/grandparental education was not related to increased rates
of hospitalization.
Conclusion
The association between school performance and hospitalization for depression depended on adolescent hospitalization or externalizing
comorbidity, suggesting that disorders with an early onset are decisive. Contrary to the social patterning of many health
outcomes, low grandparental/parental education did not appear to increase the rate of hospitalization for unipolar depression
in the offspring.
comorbidity, suggesting that disorders with an early onset are decisive. Contrary to the social patterning of many health
outcomes, low grandparental/parental education did not appear to increase the rate of hospitalization for unipolar depression
in the offspring.
- Content Type Journal Article
- Category Original Paper
- Pages 1-12
- DOI 10.1007/s00127-012-0476-y
- Authors
- Ulf Jonsson, Department of Neuroscience, Child and Adolescent Psychiatry, Uppsala University, 751 85 Uppsala, Sweden
- Anna Goodman, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
- Anne-Liis von Knorring, Department of Neuroscience, Child and Adolescent Psychiatry, Uppsala University, 751 85 Uppsala, Sweden
- Lars von Knorring, Department of Neuroscience, Psychiatry, Uppsala University, 751 85 Uppsala, Sweden
- Ilona Koupil, Centre for Health Equity Studies (CHESS), Stockholm University/Karolinska Institute, Stockholm, Sweden
- Journal Social Psychiatry and Psychiatric Epidemiology
- Online ISSN 1433-9285
- Print ISSN 0933-7954