Reliability and validity of the Cystic Fibrosis Questionnaire-Revised for children and parents in Turkey: cross-sectional study

The purpose of study was to translate Cystic Fibrosis Questionnaire-Revised (CFQ-R) into Turkish for children with cystic
fibrosis (CF) and evaluate its reliability and validity. This is the first CF-specific health-related quality of life (HRQOL)
measure validated in a Muslim country.

Fifty-one children aged 6–13 years treated at four centers in Turkey and 30 parents participated in this cross-sectional study.
Demographic characteristics and disease severity parameters were recorded for all participants. All participants completed
the parent or child versions of CFQ-R and KINDL questionnaires at enrollment. Reliability and construct validity analysis
were carried out.

Both children and parents endorsed a range of responses, with no evidence of floor or ceiling effects. Item-to-total correlations
indicated that most items were more highly correlated with their intended scale than competing scales. Good internal consistency
was found for majority of child and parent scales. CFQ-R scales correlated significantly with clinical indices of disease
severity. Good evidence of convergent validity with a generic HRQOL scale was found.

Turkish versions of CFQ-R Child and Parent instruments have demonstrated adequate reliability and validity and can be utilized
in clinical trials or integrated into clinical evaluation and follow-up of Turkish children with CF.