Abstract
Recent developments in near-infrared spectroscopy (NIRS) have enabled non-invasive clarification of brain functions in psychiatric
disorders. Functional neuroimaging studies of patients with obsessive–compulsive disorder (OCD) have suggested that the frontal
cortex and subcortical structures may play a role in the pathophysiology of the disorder. Twelve treatment-naïve children
with OCD and 12 age- and sex-matched healthy control subjects participated in the present study after giving consent. The
relative concentrations of oxyhemoglobin (oxy-Hb) were measured with prefrontal probes every 0.1 s during the Stroop color-word
task, using 24-channel NIRS machines. During the Stroop color-word task, the oxy-Hb changes in the OCD group were significantly
smaller than those in the control group in the prefrontal cortex, especially in the frontopolar cortex. The present study
suggests that children with OCD have reduced prefrontal hemodynamic response as measured by NIRS.
disorders. Functional neuroimaging studies of patients with obsessive–compulsive disorder (OCD) have suggested that the frontal
cortex and subcortical structures may play a role in the pathophysiology of the disorder. Twelve treatment-naïve children
with OCD and 12 age- and sex-matched healthy control subjects participated in the present study after giving consent. The
relative concentrations of oxyhemoglobin (oxy-Hb) were measured with prefrontal probes every 0.1 s during the Stroop color-word
task, using 24-channel NIRS machines. During the Stroop color-word task, the oxy-Hb changes in the OCD group were significantly
smaller than those in the control group in the prefrontal cortex, especially in the frontopolar cortex. The present study
suggests that children with OCD have reduced prefrontal hemodynamic response as measured by NIRS.
- Content Type Journal Article
- Category Original Article
- Pages 1-13
- DOI 10.1007/s10578-012-0323-0
- Authors
- Toyosaku Ota, Department of Psychiatry, Nara Medical University, 840 Shijyou-cho, Kashihara-shi, 634-8522 Nara, Japan
- Junzo Iida, Faculty of Nursing, Nara Medical University, Kashihara-shi, Japan
- Masayuki Sawada, Department of Psychiatry, Hannan Hospital, Sakai-shi, Japan
- Yuko Suehiro, Department of Psychiatry, Nara Medical University, 840 Shijyou-cho, Kashihara-shi, 634-8522 Nara, Japan
- Kazuhiko Yamamuro, Department of Psychiatry, Nara Medical University, 840 Shijyou-cho, Kashihara-shi, 634-8522 Nara, Japan
- Hiroki Matsuura, Department of Psychiatry, Nara Medical University, 840 Shijyou-cho, Kashihara-shi, 634-8522 Nara, Japan
- Shohei Tanaka, Department of Psychiatry, Nara Medical University, 840 Shijyou-cho, Kashihara-shi, 634-8522 Nara, Japan
- Naoko Kishimoto, Department of Psychiatry, Nara Medical University, 840 Shijyou-cho, Kashihara-shi, 634-8522 Nara, Japan
- Hideki Negoro, Department of Education, Nara University of Education, Nara-shi, Japan
- Toshifumi Kishimoto, Department of Psychiatry, Nara Medical University, 840 Shijyou-cho, Kashihara-shi, 634-8522 Nara, Japan
- Journal Child Psychiatry & Human Development
- Online ISSN 1573-3327
- Print ISSN 0009-398X