Abstract
Methods
Four models were considered: a) linear regression using total OHS as a continuous regressor; b) linear regression employing
responses to the twelve OHS questions as categorical predictors; c) two-part approach combining logistic and linear regression;
and d) response mapping. The models were internally validated on the estimation data set, which included OHS and EQ-5D scores
for total hip replacements, both before and six months after procedure for 1,759 operations. An external validation was also
performed.
responses to the twelve OHS questions as categorical predictors; c) two-part approach combining logistic and linear regression;
and d) response mapping. The models were internally validated on the estimation data set, which included OHS and EQ-5D scores
for total hip replacements, both before and six months after procedure for 1,759 operations. An external validation was also
performed.
Results
All models estimated the mean EQ-5D score within 0.005 of an observed health-state utility estimate, ordinary least squares
(OLS) continuous being the most accurate and OLS categorical the most consistent. Age, gender and deprivation did not improve
the models. More accurate estimations at the individual level were achieved for higher scores of observed OHS and EQ-5D.
(OLS) continuous being the most accurate and OLS categorical the most consistent. Age, gender and deprivation did not improve
the models. More accurate estimations at the individual level were achieved for higher scores of observed OHS and EQ-5D.
- Content Type Journal Article
- Pages 1-11
- DOI 10.1007/s11136-012-0174-y
- Authors
- Rafael A. Pinedo-Villanueva, Wessex Institute, University of Southampton, Alpha House, Enterprise Road, Chilworth, Southampton, SO16 7NS UK
- David Turner, Wessex Institute, University of Southampton, Alpha House, Enterprise Road, Chilworth, Southampton, SO16 7NS UK
- Andrew Judge, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Windmill Road, Headington, Oxford, OX3 7LD UK
- James P. Raftery, Wessex Institute, University of Southampton, Alpha House, Enterprise Road, Chilworth, Southampton, SO16 7NS UK
- Nigel K. Arden, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Windmill Road, Headington, Oxford, OX3 7LD UK
- Journal Quality of Life Research
- Online ISSN 1573-2649
- Print ISSN 0962-9343