Abstract
Few studies have explored mediators between medication-related support and medication adherence for individuals with rare,
systemic autoimmune conditions. Using the Information-Motivation-Behavioral Skills model, we tested whether depressive symptomatology
and medication adherence self-efficacy mediated the relationship between adherence support and changes in medication adherence
among vasculitis patients, and whether support from physicians and partners differentially affected medication adherence.
Vasculitis patients (n = 172) completed baseline and follow-up questionnaires about their medication adherence and perceived adherence support.
Bootstrapped mediation analyses tested the effects of physician and partner support on changes in medication adherence. Adherence
self-efficacy mediated the relationship between physician support and changes in medication adherence (B = 0.05, SE = 0.03, 95% CI 0.01, 0.13). Neither self-efficacy nor depressive symptomatology mediated the effects of partner
support. Although physicians spend little time with patients, they can increase patients’ confidence about taking medications
correctly and potentially improve health outcomes by bolstering medication adherence.
systemic autoimmune conditions. Using the Information-Motivation-Behavioral Skills model, we tested whether depressive symptomatology
and medication adherence self-efficacy mediated the relationship between adherence support and changes in medication adherence
among vasculitis patients, and whether support from physicians and partners differentially affected medication adherence.
Vasculitis patients (n = 172) completed baseline and follow-up questionnaires about their medication adherence and perceived adherence support.
Bootstrapped mediation analyses tested the effects of physician and partner support on changes in medication adherence. Adherence
self-efficacy mediated the relationship between physician support and changes in medication adherence (B = 0.05, SE = 0.03, 95% CI 0.01, 0.13). Neither self-efficacy nor depressive symptomatology mediated the effects of partner
support. Although physicians spend little time with patients, they can increase patients’ confidence about taking medications
correctly and potentially improve health outcomes by bolstering medication adherence.
- Content Type Journal Article
- Pages 1-9
- DOI 10.1007/s10865-012-9405-5
- Authors
- Jessica K. Pepper, Department of Health Behavior and Health Education, UNC Gillings School of Global Public Health, CB#7440, Chapel Hill, NC 27599, USA
- Delesha M. Carpenter, Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina, CB#7355, Chapel Hill, NC 27599, USA
- Robert F. DeVellis, UNC Thurston Arthritis Research Center, University of North Carolina, CB# 7280, Chapel Hill, NC 27599, USA
- Journal Journal of Behavioral Medicine
- Online ISSN 1573-3521
- Print ISSN 0160-7715