Abstract
The role of estrogens in schizophrenia has been proposed from the observation of schizophrenia occurring later and with symptom
severity being lesser in women. Utility of estrogens in treatment of psychoses, though seen to be useful, comes with inherent
risks of neoplasias, given its agonistic action on breast and endometrium. This risk can be overcome with use of selective
estrogen receptor modulators, like raloxifene. Raloxifene has been used in schizophrenia, with improvement in symptoms and
cognitive functions. We report the use of raloxifene as an adjunctive treatment, with risperidone, in treatment-resistant
form of schizophrenia. The patient, a 29-year-old woman, over a 7-month follow-up period, showed significant improvement in
socio-occupational functioning, with reduction in symptom severity.
severity being lesser in women. Utility of estrogens in treatment of psychoses, though seen to be useful, comes with inherent
risks of neoplasias, given its agonistic action on breast and endometrium. This risk can be overcome with use of selective
estrogen receptor modulators, like raloxifene. Raloxifene has been used in schizophrenia, with improvement in symptoms and
cognitive functions. We report the use of raloxifene as an adjunctive treatment, with risperidone, in treatment-resistant
form of schizophrenia. The patient, a 29-year-old woman, over a 7-month follow-up period, showed significant improvement in
socio-occupational functioning, with reduction in symptom severity.
- Content Type Journal Article
- Category Case report
- Pages 1-2
- DOI 10.1007/s00737-012-0259-1
- Authors
- Eesha Sharma, The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, 560029 India
- Dhanya Raveendranathan, The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, 560029 India
- Venkataram Shivakumar, The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, 560029 India
- Naveen Jayaram, The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, 560029 India
- Naren P. Rao, The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, 560029 India
- Ganesan Venkatasubramanian, The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, 560029 India
- Journal Archives of Women’s Mental Health
- Online ISSN 1435-1102
- Print ISSN 1434-1816