Abstract
Methods
Qualitative research was conducted using six focus groups and 24 interviews with 46 CIA patients, eight interviews in patients
receiving chemotherapy with no CIA history and two interviews in patients successfully treated for CIA. Atlas.ti 5.0 was used
to organize key concepts. Cognitive interviews with 16 CIA patients and assessment of relevance of each item to CIA by 10
clinicians were also conducted to evaluate content validity.
receiving chemotherapy with no CIA history and two interviews in patients successfully treated for CIA. Atlas.ti 5.0 was used
to organize key concepts. Cognitive interviews with 16 CIA patients and assessment of relevance of each item to CIA by 10
clinicians were also conducted to evaluate content validity.
Results
Most CIA patients were white (76%) and female (83%), and the average age was 60 years. The most common cancer types were breast
cancer (54%) and lung cancer (17%). Tiredness was the most prevalent symptom and rated as the most important by 83% of CIA
patients; weakness, shortness of breath, lightheadedness, and dizziness were ranked next in importance. The final anemia impact
measure (AIM) contains: (1) daily CIA symptom diary (9 items), and (2) impact of CIA-related tiredness (29 items covering
daily living activities, social activities, cognitive function, and emotions). Cognitive interviews found that the AIM was
relevant and easy to understand.
cancer (54%) and lung cancer (17%). Tiredness was the most prevalent symptom and rated as the most important by 83% of CIA
patients; weakness, shortness of breath, lightheadedness, and dizziness were ranked next in importance. The final anemia impact
measure (AIM) contains: (1) daily CIA symptom diary (9 items), and (2) impact of CIA-related tiredness (29 items covering
daily living activities, social activities, cognitive function, and emotions). Cognitive interviews found that the AIM was
relevant and easy to understand.
- Content Type Journal Article
- Pages 1-12
- DOI 10.1007/s11136-011-0034-1
- Authors
- Leah Kleinman, Outcomes Research, United BioSource Corporation, United BioSource Corporation, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA
- Katy Benjamin, Outcomes Research, United BioSource Corporation, United BioSource Corporation, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA
- Hema Viswanathan, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA, USA
- Maria Stoeckl Mattera, Outcomes Research, United BioSource Corporation, United BioSource Corporation, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA
- Linda Bosserman, Wilshire Oncology Medical Group, Rancho Cucamonga, CA, USA
- Douglas W. Blayney, Stanford Cancer Center, Stanford, CA, USA
- Dennis A. Revicki, Outcomes Research, United BioSource Corporation, United BioSource Corporation, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA
- Journal Quality of Life Research
- Online ISSN 1573-2649
- Print ISSN 0962-9343