Using a sample of 1708 team members in 292 team-based establishments, we examine the relationship between team member stress, and team autonomy in the form of team decision making, team leader appointment, and team responsibility. We also examine the relationship between stress, and intrateam interdependence in the form of team member interdependency and team-based job rotation. We further examine whether the relationships between team design and stress are mediated by team member job demands and job control. We find that an increase in job demands indirectly mediates the positive relationships between team decision making and team responsibility, and stress. We also find that a decrease in job demands indirectly mediates the negative relationship between team-based job rotation and stress. Our results suggest that the optimal design of a team, with respect to stress, is a team that has a low degree of autonomy and a high degree of intrateam interdependence.