There are significant points of similarity between considerations of self-harm and suicide in Buddhist and non-Buddhist traditions, including qualified acceptance of certain forms of self-harm, altruism as a motivation for suicide, and self-immolation as a form of political protest. Differences include specific contexts in which certain forms of self-harm are accepted and the predominant frameworks used to interpret such acts. The integration of Buddhist concepts of dukkha (unsatisfactoriness or suffering) and sati (mindfulness) into Western psychotherapeutic paradigms represents a significant point of convergence between the two traditions, and suggests the possibility of greater dialogue and therapeutic benefit in the future.