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Remission and Recovery and their Predictors in Schizophrenia Spectrum Disorder: Results from a 1-Year Follow-Up Naturalistic Trial

Abstract  

Remission and recovery are major outcome goals in schizophrenia yet their predictors have not been studied in detail. Therefore,
186 patients were examined regarding remission and recovery including their potential sociodemographic and clinical predictors
1 year after discharge. Remission was defined according to the consensus remission criteria and recovery following the definition
by Liberman et al. (2002). Of the 186 patients 54% achieved remission and 26% recovery at the 1-year follow-up. The remission
status at discharge was found to significantly influence remission and recovery at follow-up. A higher SOFAS score (P = 0.0002) as well as a positive attitude towards treatment at discharge (P = 0.0038) were identified to be significant predictors of remission at 1-year follow-up. Having a job (P = <0.0001) and being without pharmacological treatment at follow-up (P = 0.0113) were found to be significantly predictive of recovery. Our results underline the need to implement more specific
treatment strategies to improve long-term outcome.

  • Content Type Journal Article
  • Category Original Paper
  • Pages 1-21
  • DOI 10.1007/s11126-011-9193-z
  • Authors
    • Rebecca Schennach, Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    • Michael Riedel, Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    • Michael Obermeier, Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    • Markus Jäger, Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    • Max Schmauss, Psychiatric Clinic, District Hospital, Augsburg, Germany
    • Gerd Laux, Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg/Inn, Germany
    • Herbert Pfeiffer, Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Germany
    • Dieter Naber, Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Germany
    • Lutz G. Schmidt, Department of Psychiatry and Psychotherapy, University of Mainz, Mayence, Germany
    • Wolfgang Gaebel, Department of Psychiatry and Psychotherapy, Heinrich-Heine-University, Duesseldorf, Germany
    • Joachim Klosterkötter, Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
    • Isabella Heuser, Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Germany
    • Wolfgang Maier, Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    • Matthias R. Lemke, Department of Psychiatry and Psychotherapy, Alsterdorf Hospital, Hamburg, Germany
    • Eckart Rüther, Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Germany
    • Stefan Klingberg, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany
    • Markus Gastpar, Department of Psychiatry and Psychotherapy, University of Essen, Essen, Germany
    • Florian Seemüller, Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    • Hans-Jürgen Möller, Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany