African Americans have evidenced lower rates of suicide relative to the general population despite being exposed to higher levels of risk factors. This paradox has been proposed to be a result of protective factors such as religiosity and higher levels of familial involvement. The purpose of this study is to further investigate protective and risk factors of suicide in a sample of African Americans and a similar sample of Caucasians. Suicide risk and protective factors were examined in relation to the constructs of the interpersonal-psychological theory of suicide (burdensomeness, belongingness, and acquired capability), hope theory (hope, goals, pathways, and agency), and religiosity. It was hypothesized that African Americans would have higher levels of both protective factors and risk factors relative to the Caucasians. Results were partially consistent with this hypothesis.