Abstract
Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans,
with the Aberrant Behavior Checklist-Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration
examined the psychometric properties of the ABC-C in 630 individuals (ages 3–25) with FXS using exploratory and confirmatory
factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability,
Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from
individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C
scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical
trials.
with the Aberrant Behavior Checklist-Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration
examined the psychometric properties of the ABC-C in 630 individuals (ages 3–25) with FXS using exploratory and confirmatory
factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability,
Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from
individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C
scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical
trials.
- Content Type Journal Article
- Category Original Paper
- Pages 1-16
- DOI 10.1007/s10803-011-1370-2
- Authors
- Stephanie M. Sansone, Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis Medical Center, 2825 50th Street, Sacramento, CA 95817, USA
- Keith F. Widaman, Department of Psychology, University of California, Davis, One Shields Avenue, Davis, CA, USA
- Scott S. Hall, Department of Psychiatry and Behavioral Sciences, Center for Interdisciplinary Brain Sciences Research, Stanford University, 401 Quarry Road, Stanford, CA, USA
- Allan L. Reiss, Department of Psychiatry and Behavioral Sciences, Center for Interdisciplinary Brain Sciences Research, Stanford University, 401 Quarry Road, Stanford, CA, USA
- Amy Lightbody, Department of Psychiatry and Behavioral Sciences, Center for Interdisciplinary Brain Sciences Research, Stanford University, 401 Quarry Road, Stanford, CA, USA
- Walter E. Kaufmann, Center for Genetic Disorders of Cognition and Behavior, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Elizabeth Berry-Kravis, Departments of Pediatrics, Neurological Sciences, Biochemistry, Rush University Medical Center, Chicago, IL, USA
- Ave Lachiewicz, Departments of Pediatrics and Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
- Elaine C. Brown, Private Practice, Reno, NV, USA
- David Hessl, Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis Medical Center, 2825 50th Street, Sacramento, CA 95817, USA
- Journal Journal of Autism and Developmental Disorders
- Online ISSN 1573-3432
- Print ISSN 0162-3257