Abstract
The Research Units on Pediatric Psychopharmacology—Autism Network reported additional benefit when adding parent training
(PT) to antipsychotic medication in children with autism spectrum disorders and serious behavior problems. The intent-to-treat
analyses were rerun with putative predictors and moderators. The Home Situations Questionnaire (HSQ) and the Hyperactivity/Noncompliance subscale of the Aberrant Behavior Checklist were used as outcome measures. Candidate predictors and moderators included 21 demographics and baseline measures of behavior.
Higher baseline HSQ scores predicted greater improvement on the HSQ regardless of treatment assignment, but no other predictors
of outcome were observed. None of the variables measured in this study moderated response to PT. Antipsychotic medication
plus PT appears to be equally effective for children with a wide range of demographic and behavioral characteristics.
(PT) to antipsychotic medication in children with autism spectrum disorders and serious behavior problems. The intent-to-treat
analyses were rerun with putative predictors and moderators. The Home Situations Questionnaire (HSQ) and the Hyperactivity/Noncompliance subscale of the Aberrant Behavior Checklist were used as outcome measures. Candidate predictors and moderators included 21 demographics and baseline measures of behavior.
Higher baseline HSQ scores predicted greater improvement on the HSQ regardless of treatment assignment, but no other predictors
of outcome were observed. None of the variables measured in this study moderated response to PT. Antipsychotic medication
plus PT appears to be equally effective for children with a wide range of demographic and behavioral characteristics.
- Content Type Journal Article
- Pages 1-8
- DOI 10.1007/s10803-011-1338-2
- Authors
- Cristan Farmer, Ohio State University, McCampbell Hall, Rm. 305, 1581 Dodd Drive, Columbus, OH 43210, USA
- Luc Lecavalier, Ohio State University, McCampbell Hall, Rm. 305, 1581 Dodd Drive, Columbus, OH 43210, USA
- Sunkyung Yu, Yale University, New Haven, CT, USA
- L. Eugene Arnold, Ohio State University, McCampbell Hall, Rm. 305, 1581 Dodd Drive, Columbus, OH 43210, USA
- Christopher J. McDougle, Indiana University, Bloomington, IN, USA
- Lawrence Scahill, Yale University, New Haven, CT, USA
- Benjamin Handen, University of Pittsburgh, Pittsburgh, PA, USA
- Cynthia R. Johnson, University of Pittsburgh, Pittsburgh, PA, USA
- Kimberly A. Stigler, Indiana University, Bloomington, IN, USA
- Karen Bearss, Yale University, New Haven, CT, USA
- Naomi B. Swiezy, Indiana University, Bloomington, IN, USA
- Michael G. Aman, Ohio State University, McCampbell Hall, Rm. 305, 1581 Dodd Drive, Columbus, OH 43210, USA
- Journal Journal of Autism and Developmental Disorders
- Online ISSN 1573-3432
- Print ISSN 0162-3257