This study examines the effect of the Family Check Up (FCU) intervention on the probability of arrests from age 12 to 17 years for youth following heterogeneous developmental trajectories of antisocial behavior. Latent Growth Mixture Modeling results supported the presence of three developmental trajectories of arrests, including a large group of youth with few police contacts, a smaller group of youth showing early-onset and chronic arrests, and a group with Adolescent-Onset arrests. In line with hypotheses, effects of intervention were seen within the Adolescent-Onset group, but not in the early-onset chronic arrest trajectory group, or in those youth with little police contact. The trajectory groups were differentiated by peer, family, behavioral, and academic risk variables at age 11.