Abstract
This study aimed to evaluate the effect of estrogen replacement therapy on verbal cognitive performance of middle-aged postmenopausal
women. Middle-aged (40 to 59 years) hysterectomized, oligosymptomatic women receiving 0.625 mg/day of conjugated equine estrogens
(N = 27) or placebo (N = 32) in a double-blind parallel group design were compared according to their performance on a verbal memory battery before
and after six 28-day cycles of treatment. Both groups had similar age and educational level. The estrogen group performed
better on digit span-forward and on the recall of the easy stimuli on the verbal-paired associates test regardless of age,
education, physical symptoms, number of years of menopause, or blood estradiol levels. However, the small magnitude of difference
in the effect on attentional span suggests that the estrogen-related improvement is unlikely to be of clinical relevance.
Estrogen replacement therapy did not improve verbal memory in middle-aged, hysterectomized, postmenopausal, asymptomatic women.
women. Middle-aged (40 to 59 years) hysterectomized, oligosymptomatic women receiving 0.625 mg/day of conjugated equine estrogens
(N = 27) or placebo (N = 32) in a double-blind parallel group design were compared according to their performance on a verbal memory battery before
and after six 28-day cycles of treatment. Both groups had similar age and educational level. The estrogen group performed
better on digit span-forward and on the recall of the easy stimuli on the verbal-paired associates test regardless of age,
education, physical symptoms, number of years of menopause, or blood estradiol levels. However, the small magnitude of difference
in the effect on attentional span suggests that the estrogen-related improvement is unlikely to be of clinical relevance.
Estrogen replacement therapy did not improve verbal memory in middle-aged, hysterectomized, postmenopausal, asymptomatic women.
- Content Type Journal Article
- Pages 1-7
- DOI 10.1007/s00737-011-0230-6
- Authors
- Clarice Gorenstein, Instituto de Psiquiatria, LIM-23 Rua Ovidio Pires de Campos, 785 – térreo, CEP 05403-010 São Paulo, Brazil
- Joel Rennó, Institute of Psychiatry of HCFMUSP, São Paulo, Brazil
- Antônio Hélio Guerra Vieira Filho, Institute of Psychiatry of HCFMUSP, São Paulo, Brazil
- Arlete Gianfaldoni, Department of Gynecology and Obstetrics of FMUSP, São Paulo, Brazil
- Marcelo Alfonso Gonçalves, Department of Gynecology and Obstetrics of FMUSP, São Paulo, Brazil
- Hans Wolfgang Halbe, Department of Obstetrics and Gynecology, Medical School of Marília, São Paulo, Brazil
- César Eduardo Fernandes, Department of Gynecology and Obstetrics of FMUSP, São Paulo, Brazil
- Frederico Navas Demétrio, Institute of Psychiatry of HCFMUSP, São Paulo, Brazil
- Journal Archives of Women’s Mental Health
- Online ISSN 1435-1102
- Print ISSN 1434-1816