Abstract
Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain
reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations
between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis
of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated
with ASD and specific childhood behavioral outcomes.
reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations
between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis
of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated
with ASD and specific childhood behavioral outcomes.
- Content Type Journal Article
- Category Original Paper
- Pages 1-11
- DOI 10.1007/s10803-011-1378-7
- Authors
- Daniel Braunschweig, Division of Rheumatology/Allergy and Clinical Immunology, University of California, Davis, 451 E. Health Sciences Drive, Suite 6510 GBSF, Davis, CA 95616, USA
- Paul Duncanson, Division of Rheumatology/Allergy and Clinical Immunology, University of California, Davis, 451 E. Health Sciences Drive, Suite 6510 GBSF, Davis, CA 95616, USA
- Robert Boyce, Division of Rheumatology/Allergy and Clinical Immunology, University of California, Davis, 451 E. Health Sciences Drive, Suite 6510 GBSF, Davis, CA 95616, USA
- Robin Hansen, Department of Pediatrics, University of California, Davis, Davis, CA, USA
- Paul Ashwood, Department of Medical Microbiology and Immunology, University of California, Davis, Davis, CA, USA
- Isaac N. Pessah, Department of Veterinary Molecular Biosciences, University of California, Davis, Davis, CA, USA
- Irva Hertz-Picciotto, Department of Public Health Sciences, Division of Epidemiology, University of California, Davis, Davis, CA, USA
- Judy Van de Water, Division of Rheumatology/Allergy and Clinical Immunology, University of California, Davis, 451 E. Health Sciences Drive, Suite 6510 GBSF, Davis, CA 95616, USA
- Journal Journal of Autism and Developmental Disorders
- Online ISSN 1573-3432
- Print ISSN 0162-3257