In this article, the author has examined the relationships between the “central dynamic sequence” discovered by Davanloo and the activation of specific neuronal systems in the brain. The participation of defined brain areas is postulated in the clinical expression of “superego pathology”. A hypothesis regarding the involvement of subcortical structures in the central neurotic mechanism is proposed. According to this view, human neurosis results from a functional disorder of the brain which can be corrected by the specific interventions of the “system for short-term dynamic psychotherapy” discovered by Davanloo. Copyright © 1992 John Wiley & Sons, Ltd.