Aims. Ecstasy, the street name for 3,4-meththylenedioxymethamphetamine, has been associated with a range of psychiatric symptoms and impaired psychological health in both problem and recreational users. The purpose of the present paper is to determine how these impairments are related to the history of polydrug use, and the conditions under which individuals ingest ecstasy.
Design. Associations between the variables of interest were investigated utilising negative binomial regression.
Setting. Liverpool and Preston in the North West of England.
Participants. A convenience sample of 159 recreational ecstasy/polydrug users, (80 males, 79 females). The sample was composed primarily of undergraduates.
Main Outcome Measures. The dependent variable was the number of reported ecstasy-related adverse effects. Independent variables included quantitative aspects of ecstasy and other drug use, and the various beliefs and behaviours associated with ecstasy use.
Results. The number of adverse effects was positively associated with lifetime exposure to ecstasy and negatively associated with period of abstinence from the drug. Adverse effects were more common among those who consumed ecstasy and alcohol concurrently, but were unrelated to other aspects of polydrug use. They were unaffected by whether the user took precautions when using the drug, and only weakly related to prior beliefs concerning the effects of ecstasy.
Conclusions. Greater lifetime exposure to ecstasy and consuming the drug concurrently with alcohol, increase the likelihood of experiencing adverse effects including paranoia, poor general health, irritability, confusion, and moodiness. Adverse effects decrease with the period of abstinence from the drug.