Stigma is a significant barrier to the improvement of the lives of people with schizophrenia. Little is known about the emergence of stigmatizing attitudes developmentally. The purpose of this study was to provide a provincial assessment of adolescent knowledge about schizophrenia and to identify the relationship between adolescent knowledge and social distance toward people with schizophrenia. Data were derived from the 2005 cycle of the Ontario Student Drug Use and Health Survey. In total, 3,117, 7th- to 12th-graders completed self-administered questionnaires that included a measure of schizophrenia knowledge and social distancing. Results indicated that the majority of adolescents had some knowledge about schizophrenia and low social distancing toward people with schizophrenia. Greater knowledge, increasing age, being female, and lower parental education were associated with less distancing attitudes. Educational campaigns to reduce stigma may still be warranted as one component of broader multilevel interventions to overcome mental illness stigma. © 2010 Wiley Periodicals, Inc.