NIH
The team began by mapping networks over time in six people with major depression and 37 healthy controls. They found that the salience network, which includes brain regions in the frontal cortex and striatum, was almost twice as large on average in people with depression. This network is involved in reward processing and determining what to pay attention to. The size of the salience network did not change over time in people with or without depression. Nor did it relate to depression symptoms in people with depression.