Lauded for their contributions to statistics, psychology, and psychometrics, the authors make statistical methods relevant to readers’ day-to-day lives by including real historical situations that demonstrate the role of statistics in reasoning and decision making. The historical vignettes encompass the English case of Sally Clark, breast cancer screening, risk and gambling, the Federal Rules of Evidence, “high-stakes” testing, regulatory issues in medicine, difficulties with observational studies, ethics in human experiments, health statistics, and much more. In addition to these topics, seven U.S. Supreme Court decisions reflect the influence of statistical and psychometric reasoning and interpretation/misinterpretation.