Abstract
This is a systematic review of eighty-two published studies investigating the impact of DSM-IV mental disorders on combination
antiretroviral therapy (cART) adherence and persistence among persons living with HIV/AIDS (PLWHA). Sixty-two articles examined
depression, with 58 % (N = 32/62) finding lower cART adherence and persistence. Seventeen articles examined one or more anxiety disorders, with the
majority finding no association with cART adherence or persistence. Eighty percent of the studies that evaluated the impact
of psychotic (N = 3), bipolar (N = 5) and personality disorders (N = 2) on cART adherence and persistence also found no association. Seven out of the nine studies (78 %) evaluating the impact
of antidepressant treatment (ADT) on cART adherence found improvement. Adherence and depression measurements varied significantly
in studies; common research measurements would improve data harmonization. More research specifically addressing the impact
of other mental disorders besides depression on cART adherence and RCTs evaluating ADT on cART adherence are also needed.
antiretroviral therapy (cART) adherence and persistence among persons living with HIV/AIDS (PLWHA). Sixty-two articles examined
depression, with 58 % (N = 32/62) finding lower cART adherence and persistence. Seventeen articles examined one or more anxiety disorders, with the
majority finding no association with cART adherence or persistence. Eighty percent of the studies that evaluated the impact
of psychotic (N = 3), bipolar (N = 5) and personality disorders (N = 2) on cART adherence and persistence also found no association. Seven out of the nine studies (78 %) evaluating the impact
of antidepressant treatment (ADT) on cART adherence found improvement. Adherence and depression measurements varied significantly
in studies; common research measurements would improve data harmonization. More research specifically addressing the impact
of other mental disorders besides depression on cART adherence and RCTs evaluating ADT on cART adherence are also needed.
- Content Type Journal Article
- Category Substantive Review
- Pages 1-25
- DOI 10.1007/s10461-012-0212-3
- Authors
- Sandra A. Springer, Yale AIDS Program, Yale University School of Medicine, 135 College Street, Suite 323, New Haven, CT 06511, USA
- Azem Dushaj, Yale AIDS Program, Yale University School of Medicine, 135 College Street, Suite 323, New Haven, CT 06511, USA
- Marwan M. Azar, Yale AIDS Program, Yale University School of Medicine, 135 College Street, Suite 323, New Haven, CT 06511, USA
- Journal AIDS and Behavior
- Online ISSN 1573-3254
- Print ISSN 1090-7165