Abstract
Schizophrenia and intellectual disability (ID) co-occur three times more than would be expected by chance. This has led to
speculation that a particular form of schizophrenia may give rise to both the symptoms of schizophrenia and the intellectual
impairment. If this was the case, one may expect the presentation of schizophrenia in an ID population to differ from that
in a population with average/high IQ. A systematic review and meta-analysis was undertaken of studies comparing the clinical
presentation of schizophrenia in people with mild/borderline ID to that in people with average/high IQ. Five studies were
eligible for inclusion. Four reported more negative symptoms in the ID population, while two reported more positive symptoms.
Meta-analysis demonstrated that the ID population experienced more negative symptoms. The available evidence supports the
proposal that the clinical presentation of schizophrenia in an ID population differs from that in a population with normal
IQ.
speculation that a particular form of schizophrenia may give rise to both the symptoms of schizophrenia and the intellectual
impairment. If this was the case, one may expect the presentation of schizophrenia in an ID population to differ from that
in a population with average/high IQ. A systematic review and meta-analysis was undertaken of studies comparing the clinical
presentation of schizophrenia in people with mild/borderline ID to that in people with average/high IQ. Five studies were
eligible for inclusion. Four reported more negative symptoms in the ID population, while two reported more positive symptoms.
Meta-analysis demonstrated that the ID population experienced more negative symptoms. The available evidence supports the
proposal that the clinical presentation of schizophrenia in an ID population differs from that in a population with normal
IQ.
- Content Type Journal Article
- Pages 1-8
- DOI 10.1007/s10862-011-9224-y
- Authors
- Killian A. Welch, Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK EH10 5HF
- Stephen M. Lawrie, Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK EH10 5HF
- Walter Muir, Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK EH10 5HF
- Eve C. Johnstone, Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK EH10 5HF
- Journal Journal of Psychopathology and Behavioral Assessment
- Online ISSN 1573-3505
- Print ISSN 0882-2689