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Although several studies have explored psilocybin for depression, many have focused on people whose symptoms had not responded to other treatments (so-called “treatment-resistant depression”). We wanted to test whether the drug could also help people with more common forms of depression. At just eight days, those who received psilocybin showed noticeable improvements in mood. And by the end of the six-week follow-up period, more than half of participants in the psilocybin group no longer met the criteria for depression. In the placebo group, only one person showed the same level of improvement.