This commentary highlights the potential of case–control studies to strengthen the evidence base for injury prevention in low- and middle-income countries (LMICs). We argue that these designs are especially valuable in information-poor settings and across the full spectrum of injury topics—both unintentional and intentional. Our aim is to foster LMIC-led collaborations that build research capacity, support rigorous local studies and generate evidence that can inform policy and practice. We invite interested researchers to join this initiative.
Injuries are a leading cause of death and disability worldwide. The health loss from unintentional and intentional injuries exceeds that from HIV/AIDS, tuberculosis and malaria combined—diseases long recognised as major global health priorities.