A growing number of researchers use public health critical race praxis (PHCRP), an antiracism framework derived in part from critical race theory, to conceptualize racism as a public health problem and examine its contributions to health and health care inequities. Critical race scholars define racism as “the state-sanctioned and/or extralegal production and exploitation of group-differentiated vulnerability to premature death,” as stated by Ruth Gilmore in her 2007 book Golden Gulag. Despite solid evidence for the prevalence and potential effects of racism, few studies provide data to guide the development, implementation, and evaluation of antiracism interventions in diverse settings (e.g., community, health care), activities that we refer to in this review as practice. A central focus of PHCRP is to guide evidence-based action to disrupt racism; therefore, the framework may be useful in guiding antiracism practice. However, evidence for its use for practice has not been established. To encourage the development, implementation, and evaluation of antiracism solutions, this review examines the evidence applying PHCRP to practice-focused research. The findings provide a baseline assessment to guide future evidence-based antiracism mitigation efforts. We offer recommendations to support future practice-focused work.