This supplement is a step forward in promoting health equity and a race-conscious approach in clinical practice and in tools, such as clinical practice guidelines (CPGs) and clinical reports (CRs). The series of important articles respond to the American Academy of Pediatrics’ call to eliminate race-based clinical guidance and calls for needed research to support the reevaluation of CPGs and CRs across key pediatric domains. Additionally, the authors not only highlight the complexities in making inferences but also delve into the pragmatic issues of implementation, highlighting consistent barriers to adopting a race-conscious approach in pediatric evidence-based medicine. It is not enough to describe disparities if there are not interventions to change outcomes. It is not enough to create race-conscious clinical guidelines if they are not used. Finally, in today’s world, implementation cannot be discussed without consideration of the impact of artificial intelligence (AI) now transforming evidence-based medicine.