Scholars have argued that practical wisdom—understood in the Aristotelian sense of phronesis—is a crucial virtue for social workers because it is essential for addressing moral challenges in practice. This article explores situations of moral uncertainty and considers how phronesis can guide social workers in navigating these challenges, reducing arbitrariness in decision-making and alleviating moral distress. Drawing primarily on theoretical analysis while also engaging with selected empirical findings, the article identifies five types of moral uncertainty and relates them to a contemporary account of phronesis comprising four central functions. The constitutive function enables social workers to discern and articulate morally salient features of a situation, thereby providing orientation and reducing uncertainty. The blueprint function offers an evaluative framework for addressing moral conflicts under conditions of moral uncertainty, while also motivating efforts to resolve those conflicts. The emotional-regulative function helps social workers evaluate and regulate their feelings of uncertainty. The integrative function facilitates the weighing of competing virtues and the formation of a coherent, reasoned judgement. This article argues that cultivating phronesis should be a central objective of ethics education in social work since it may help practitioners navigate moral uncertainty in complex professional contexts.