Amid unstable political climates and threats to government funding, social entrepreneurship offers social workers a way to sustain services independently. Simultaneously, it may also help reduce burnout and improve the financial sustainability of the profession, which is often characterized by overwork and low pay. To foster the growing movement toward social entrepreneurship within the profession, it’s essential to first understand the current landscape. This study examines the personality traits, professional factors, and demographic variables that predict social entrepreneurship in social work by comparing social workers in the US that engage in entrepreneurship and those that do not. Using responses from a national survey of social workers, we found that prior training in social entrepreneurship and higher risk-taking tolerance were the only two significant factors in predicting engagement. We also found differences in personal traits and professional factors between the two groups. The findings underscore the importance of integrating entrepreneurship-focused programming into both educational curricula and professional development programs within social work.