In multicultural societies, social entrepreneurship in social work has become essential for providing innovative solutions to the social problems faced by minority communities. A knowledge gap remains regarding social entrepreneurship in cultural contexts, particularly in understanding how social workers develop and operate social enterprises that address culturally sensitive issues. This study presents qualitative research conducted in two countries—the United States and Israel, using social enterprises that respond to childhood sexual abuse (CSA) within the Orthodox-Jewish community as a case study. Adopting a constructivist paradigm and purposive sampling, nine organizations were identified, and in-depth interviews were conducted with all affiliated social workers. The findings reveal that, in order to develop and tailor ventures to the cultural contexts of minority communities, social work entrepreneurs must navigate various pitfalls and adopt culturally adapted action strategies. These include multi-level community engagement; building trust through direct and transparent communication; leveraging religious leadership as agents of change; culturally adaptive language, visual representation, and terminology; and integrating religious and therapeutic principles. This research highlights the transformative potential of social entrepreneurship to promote culturally adapted responses to the unique needs of diverse minority communities.