The main research purpose was to investigate the impact of piano courses on the mental health of the elderly. The sample consisted of 30 individuals. The age range of the participants was from 60 to 70 years. For 6 months, the respondents had piano lessons two times a week. One lesson lasted 2 hours and included the development of playing skills and improvisation techniques. The results confirmed the validity of the proposed learning strategy. The Taylor anxiety scale decreased by 19 points. These results showed a decrease of more than half of its original value. The Beck test for depression decreased by 21.5 points. The result shows a decrease two times. The test on the emotional background (the WAM questionnaire) shows an improvement in Well-Being by 3.3 points. In the group of respondents, Activity increased by 3.3 points, and the Mood factor increased by 3.5 points. The direction of further research should be related to the study of the impact of musical practices on various components of the clinical picture of depression and negative emotional states. The results can find practical implementation in the practice of psychotherapeutic work in reducing anxiety and eliminating depression in the elderly in clinics, hospitals, and other medical institutions.