Self-integrity plays a vital role in the psychological wellbeing of older adults. The present study investigated whether or not the confrontation with negative, self-stereotyped information leads to a deterioration of older adults’ self-integrity. Additionally, the current study attempted to examine the mediating effects of sense of coherence and empathy on the relationship between self-stereotype and self-integrity. A total of 825 Chinese older adults aged 55 or above from Xi’an and Beijing were recruited as research participants. A self-stereotype scale, sense of coherence scale, interpersonal reactivity index and self-integrity scale were used. Results showed that self-stereotypes are negatively associated with sense of coherence, empathy and self-integrity. Furthermore, sense of coherence and empathy are positively associated with self-integrity and played important roles in mediating the relationship between self-stereotype and self-integrity. Findings of this study can contribute to an improved understanding of the mechanism of associations between self-stereotype and self-integrity in older adults. Lastly, results obtained can provide guidance for effectively improving older adults’ self-integrity to limit the negative effects of self-stereotypes.