Although prior research shows that either religiosity or spirituality facilitates well-being, the interaction of both constructs in predicting positive youth development (PYD) in collectivistic contexts remains unknown. This study examined the moderating role of spirituality on the link between religiosity and PYD, including each of its Cs (i.e., competence, confidence, connection, character, and caring) among 1116 Filipino adolescents. Results demonstrate that both religiosity and spirituality are positively correlated with PYD and its dimensions. Furthermore, there is a significant interaction between religiosity and spirituality for the overall PYD construct and the socio-emotional Cs (i.e., connection, character, and caring). This study highlights the importance of young people’s sense of connection with something beyond than themselves (i.e., spirituality) in promoting adolescent thriving.