Despite consistent evidence suggesting high rates of physical and psychosocial morbidity among survivors of childhood cancer, debate has persisted: are those who are diagnosed with cancer as children, adolescents, or young adults ([CAYAs] 0 to 25 years old) at higher risk than their siblings or peers for depression, anxiety, suicide, or other mental health disorders? The article by Lee et al in this issue of JAMA Pediatrics provides the most definitive answer to date: yes. In their systematic review and meta-analysis of data from 52 studies and over 20 000 CAYA cancer survivors, they confirmed lifetime elevated risks of depression (relative risk [RR], 1.57; 95% CI, 1.29-1.92), anxiety (RR, 1.29; 95% CI, 1.14-1.47), and other psychiatric illnesses (ie, schizophrenia, RR, 1.56; 95% CI, 1.36-1.80) compared with siblings and matched peer-controls. Although they found no evidence for increased risk of death by suicide among all CAYAs, those with central nervous tumors (RR, 1.49; 95% CI, 1.08-2.05) and those diagnosed during adolescence and young adulthood (ages 15 to 19 years; RR, 1.61; 95% CI, 1.09-2.39) were at increased risk. Survivors currently older than 25 years and those with lower income, less education, lack of current employment, and poorer social supports had higher risks of poor mental health.