
The Conversation | D Herzberg/National Archives/The American Weekly
Purdue’s profit-seeking became a model for other drugmakers, distributors and pharmacy chains. The ensuing sales frenzy led to skyrocketing rates of opioid addiction and related harms by the early 2000s – perhaps the worst pharmaceutical crisis in U.S. history. Above: A 1944 article decried the dangers of prescribed opioids.