The most current version of the Millon Clinical Multiaxial Inventory, the MCMI-IV, has practically no literature outside of the manual. The research on the embedded indicators of negative response bias is scarce at this time with regard to the MCMI-IV; however, these scales largely overlap with those of the MCMI-III, so that it is reasonable to hypothesize that a similar validity will generalize to the newer version. The present article reviews data from the manual and the scientific literature to offer a review of the simulation and known-group comparison studies conducted with the MCMI-III. The use of the Modifier Indices is discussed, as well as the scale patterns expected with records suggesting a negative response bias. As a conclusion, we offer a list of recommendations for future studies with the MCMI-IV.